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Mantle cell lymphoma
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma (NHL), comprising about 6% of NHL cases.〔(Mantle Cell Lymphoma Facts )〕〔 There are only about 15,000 patients presently in the U.S. (The prevalence seems to be somewhat higher in Europe.) MCL is difficult to treat and seldom considered cured. Median survival times were about 3 years, but are now estimated as approaching 6 years for new patients.
MCL is a subtype of B-cell lymphoma, due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. MCL cells generally over-express cyclin D1 due to a t(11:14)〔(t(11;14)(q13;q32) )〕 chromosomal translocation in the DNA. More specifically, the translocation is at t(11;14)(q13;q32).
==Symptoms==
At diagnosis, patients typically are in their 60s and present to their physician with advanced disease. About half have either fever, night sweats, or unexplained weight loss (over 10% of body weight). Enlarged lymph nodes (for example, a "bump" on the neck, armpits or groin) or splenomegaly are usually present. Bone marrow, liver and GI tract involvement occurs relatively early in the course of the disease.〔http://www.lls.org/content/nationalcontent/resourcecenter/freeeducationmaterials/lymphoma/pdf/mantlecelllymphoma.pdf〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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